This report from the Institute of Medicine (IOM) reviews and makes recommendations for using integrated measures of morbidity and mortality (such as quality-adjusted life years, or QALYs); reporting cost-effectiveness ratios; and data and research needs to improve regulatory cost-effectiveness analysis.
It also considers the ethical implications of using cost-effectiveness analysis, and integrated measures of health impact, in regulatory policy development.
www.iom.edu/CMS/3809/19739/32029.aspx